We are in the downward leg of the 5th innovation wave, a wave enabled by core technologies from the genomics revolution and the now defunct Moore’s Law. While there are opportunities to make money if you bet correctly on the rise of the 6th wave, we believe that over the next decade of outsized venture returns will be realized not by chasing the next hot shiny technology but rath- er by investing in EOI companies: enterprises with the vision, focus on exe- cution, and capacity to tackle large and often antiquated industries—from education and healthcare to payment and oil and gas. Winning in this age will require operational excellence. But the rewards will merit the effort. Despite its massive growth, Information Technology today only accounts for 5% of the US GDP. It’s time venture capitalist tackle the remaining 95%.